Of P and Z: Mitochondrial tRNA processing enzymes
نویسندگان
چکیده
منابع مشابه
RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing Enzyme
tRNAs are synthesized as immature precursors, and on their way to functional maturity, extra nucleotides at their 5' ends are removed by an endonuclease called RNase P. All RNase P enzymes characterized so far are composed of an RNA plus one or more proteins, and tRNA 5' end maturation is considered a universal ribozyme-catalyzed process. Using a combinatorial purification/proteomics approach, ...
متن کاملHuman RNase P: a tRNA-processing enzyme and transcription factor
Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5' leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcription with processing in the regulation of tRNA gene expression. However, RNase P is also essent...
متن کاملLoss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila
Proteins encoded by mitochondrial DNA are translated using mitochondrially encoded tRNAs and rRNAs. As with nuclear encoded tRNAs, mitochondrial tRNAs must be processed to become fully functional. The mitochondrial form of ribonuclease P (mt:RNase P) is responsible for 5'-end maturation and is comprised of three proteins; mitochondrial RNase P protein (MRPP) 1 and 2 together with proteinaceous ...
متن کاملCommutativity degree of $mathbb{Z}_p$≀$mathbb{Z}_{p^n}
For a nite group G the commutativity degree denote by d(G) and dend:$$d(G) =frac{|{(x; y)|x, yin G,xy = yx}|}{|G|^2}.$$ In [2] authors found commutativity degree for some groups,in this paper we nd commutativity degree for a class of groups that have high nilpontencies.
متن کاملAlteration of a mitochondrial tRNA precursor 5' leader abolishes its cleavage by yeast mitochondrial RNase P.
A mitochondrial specific RNase P is required to process 5' leaders from mitochondrial tRNA precursors in Saccharomyces cerevisiae. Experiments with a pair of mitochondrial pretRNAs(Asp) having leaders of different base composition suggest that this enzyme is unexpectedly sensitive to leader sequence or structure. Asp-AU (75% AU leader) is cleaved by the mitochondrial RNase P while Asp-GC (39% A...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
سال: 2012
ISSN: 1874-9399
DOI: 10.1016/j.bbagrm.2011.11.003